Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs

R S Bagley; M L Harrington; G E Pluhar; R D Keegan; S A Greene; M P Moore; P R Gavin

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Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs

Journal article

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Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs

R S Bagley, M L Harrington, G E Pluhar, R D Keegan, S A Greene, M P Moore and P R Gavin

American journal of veterinary research, Vol.57(1), pp.116-119

01/1996

Handle:

https://hdl.handle.net/2376/110470

PMID: 8720249

Abstract

Blood Pressure

Intracranial Pressure - drug effects

Brain - anatomy & histology

Diuretics - pharmacology

Adrenal Cortex Hormones - pharmacology

Dura Mater - surgery

Reference Values

Intracranial Pressure - physiology

Brain - drug effects

Animals

Methylprednisolone - pharmacology

Analysis of Variance

Craniotomy - veterinary

Dogs - physiology

Craniotomy - methods

Hyperventilation - physiopathology

Dura Mater - physiology

Furosemide - pharmacology

To determine the effect of craniectomy and durotomy on intracranial pressure (ICP) in clinically normal dogs. Two-part study (experiments A and B) involving craniectomy and durotomy, with and without treatments to lower ICP. Six (experiment A) and 7 (experiment B) healthy dogs. In experiment A, craniectomy was performed in combination with durotomy, diuretic administration, methylprednisolone sodium succinate administration, and hyperventilation, and effect of these manipulations on ICP was determined. In experiment B, dogs had only craniectomy and durotomy without associated ICP-lowering treatments. During both experiments, ICP was monitored throughout the surgical procedure with a fiber optic ICP monitoring device. Intracranial pressure decreased after the combination of craniectomy, durotomy, and other ICP-lowering treatments in dogs of experiment A. Similar magnitude of decrease in ICP was observed in dogs of experiment B after craniectomy and durotomy. Comparison of these experiments indicate that surgical removal of overlying skull and incision of the dura mater can significantly decrease ICP in clinically normal dogs. Craniectomy and durotomy may be useful as an adjunct treatment for increased ICP.

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Title: Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs
Creators: R S Bagley - Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164-6610, USA
M L Harrington
G E Pluhar
R D Keegan
S A Greene
M P Moore
P R Gavin
Publication Details: American journal of veterinary research, Vol.57(1), pp.116-119
Academic Unit: Veterinary Clinical Sciences, Department of
Publisher: United States
Identifiers: 99900547254301842
Language: English
Resource Type: Journal article

Effect of craniectomy/durotomy alone and in combination with hyperventilation, diuretics, and corticosteroids on intracranial pressure in clinically normal dogs

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