Journal article
Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats
American journal of veterinary research, Vol.65(5), pp.586-591
05/2004
Handle:
https://hdl.handle.net/2376/106771
PMID: 15141877
Abstract
To compare effects of short-term administration of a soy diet with those of a soy-free diet on serum thyroid hormone concentrations in healthy adult cats.
18 healthy adult cats.
Cats were randomly assigned to receive either a soy or soy-free diet for 3 months each in a crossover design. Assays included CBC, serum biochemical profile, thyroid hormone analysis, and measurement of urinary isoflavone concentrations.
Genistein, a major soy isoflavone, was identified in the urine of 10 of 18 cats prior to dietary intervention. Compared with the soy-free diet, cats that received the soy diet had significantly higher total thyroxine (T4) and free T4 (fT4) concentrations, but unchanged total triiodothyronine (T3) concentrations. The T3/fT4 ratio was also significantly lower in cats that received the soy diet. Although the magnitudes of the increases were small (8% for T4 and 14% for fT4), these changes resulted in an increased proportion of cats (from 1/18 to 4/18) that had fT4 values greater than the upper limit of the laboratory reference range. There was no significant effect of diet on any other measured parameter.
Short-term administration of dietary soy has a measurable although modest effect on thyroid hormone homeostasis in cats. Increase in T4 concentration relative to T3 concentration may result from inhibition of 5'-iodothyronine deiodinase or enhanced T3 clearance. Soy is a common dietary component that increases serum T4 concentration in cats.
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Details
- Title
- Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats
- Creators
- Heidi L White - Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USALisa M FreemanOrla MahonyPeter A GrahamQin HaoMichael H Court
- Publication Details
- American journal of veterinary research, Vol.65(5), pp.586-591
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- United States
- Grant note
- R01-GM-61834 / NIGMS NIH HHS
- Identifiers
- 99900547073001842
- Language
- English
- Resource Type
- Journal article