Journal article
Effect of hyperbaric oxygen on chemotherapy-induced neuropathy in male and female rats
Behavioural pharmacology, Vol.31(1), pp.61-72
02/2020
PMID: 31503072
Abstract
Chemotherapeutic agents can cause peripheral neuropathy, a deleterious side effect of cancer treatment. Hyperbaric oxygen (HBO2) treatment has shown great potential for decreasing pain in numerous clinical pain conditions and in preclinical studies. This study was designed to test whether HBO2 might also be useful for treating chemotherapy-induced peripheral neuropathy. Male and female Sprague-Dawley rats were injected with 1 mg/kg paclitaxel or vehicle every other day for 7 days to induce allodynia, followed by either one single, or four daily 60-min exposures to HBO2 or room air. Mechanical and cold allodynia as well as locomotor behavior and body weight were assessed intermittently for several weeks. Estrous cycling was also tracked in female rats. Paclitaxel caused pronounced mechanical allodynia in both sexes that was completely reversed by either one or four treatments of HBO2. Females in all treatment groups showed greater cold acetone scores than males, and acetone scores were not reliably reduced by HBO2 treatment. Neither paclitaxel nor HBO2 treatment altered locomotor behavior or estrous cycling. We conclude that HBO2 treatment was highly effective at reducing mechanical allodynia in paclitaxel-treated rats without affecting weight gain, locomotion, or estrous cycling, suggesting that HBO2 may be effective for treating chemotherapy-induced neuropathic pain without producing significant side effects.
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Details
- Title
- Effect of hyperbaric oxygen on chemotherapy-induced neuropathy in male and female rats
- Creators
- Abigail L Brewer - Washington State UniversityDonald Y Shirachi - University of the PacificRaymond M Quock - Washington State UniversityRebecca M Craft - Washington State University
- Publication Details
- Behavioural pharmacology, Vol.31(1), pp.61-72
- Academic Unit
- Psychology, Department of
- Identifiers
- 99900907904101842
- Language
- English
- Resource Type
- Journal article