Journal article
Effect of opioid peptide antisera on nitrous oxide antinociception in rats
Pharmacology, biochemistry and behavior, Vol.48(3), pp.699-702
1994
Handle:
https://hdl.handle.net/2376/106584
PMID: 7938124
Abstract
This study was performed to examine the effects of ICV injection of antiserum against β-endorphin (β-EP) or methionine-enkephalin (ME) on nitrous oxide-induced antinociception in rats using the hot plate test. The injection of β-EP antiserum reversed the antinociceptive effect of nitrous oxide in a dose-related manner up to 200 μg/rat. However, antagonism of nitrous oxide by 400 μg β-EP antiserum was comparable to that produced by 200 μg. On the other hand, similar amounts of ME antiserum had little effect against nitrous oxide antinociception. These findings suggest that β-EP may play an important role in the antinociceptive effect of nitrous oxide.
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Details
- Title
- Effect of opioid peptide antisera on nitrous oxide antinociception in rats
- Creators
- Shuichi Hara - Departmetn of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, USAMichael J Gagnon - Departmetn of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, USARaymond M Quock - Departmetn of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, USATakeshi Shibuya - Departmetn of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL 61107, USA
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.48(3), pp.699-702
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546829801842
- Language
- English
- Resource Type
- Journal article