Journal article
Effect of sleep deprivation on serum influenza-specific IgG
Sleep (New York, N.Y.), Vol.21(1), pp.19-24
1998
Handle:
https://hdl.handle.net/2376/104101
PMID: 9485529
Abstract
Intra-pulmonary protection against influenza virus in immune mice, largely dependent upon serum lgG, is reported to be suppressed by 7 hours of sleep deprivation following viral challenge. This implies that sleep deprivation may accelerate the catabolism of influenza-specific antibodies. To determine the effects of sleep deprivation on the catabolism of serum antibodies, BALB/c mice were passively immunized intravenously with lgG anti-influenza monoclonalantibodies and catabolism kinetics monitored for 6 days. Mice were then sleep-deprived for either 9 hours (one episode) or for 9 hours followed by 6 hours on the consecutive day (two episodes) and the serum titer of influenza-specific monoclonal antibodies monitored for an additional 8 days via ELISA. One episode of sleep-deprivation had only minor effects on lgG catabolism; however, two episodes of sleep-deprivation caused significant changes in the kinetics of lgG catabolism, resulting in elevated lgG levels (p = 0.02) for 2 days post-sleep deprivation. Elevation of serum influenza-specific lgG (p = 0.005) was also seen in actively immune mice following two episodes of sleep-deprivation. Serum chemistries ruled out dehydration as a cause of the increased antibody levels; however, some anomalies were noted: total protein and albumin were elevated, although not significantly, and P and Ca were decreased. Thus, our data do not support the hypothesis that sleep-deprivation lowers existing serum antibody titers by accelerating antibody catabolism.
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Details
- Title
- Effect of sleep deprivation on serum influenza-specific IgG
- Creators
- K B Renegar - Department of Physiology and Biophysics, University of Tennessee, Memphis, USAR FloydJ M Krueger
- Publication Details
- Sleep (New York, N.Y.), Vol.21(1), pp.19-24
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS-25378 / NINDS NIH HHS NS-01727 / NINDS NIH HHS NS-31453 / NINDS NIH HHS
- Identifiers
- 99900546996401842
- Language
- English
- Resource Type
- Journal article