Journal article
Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
Obesity facts, Vol.7(3), pp.197-210
06/2014
Handle:
https://hdl.handle.net/2376/105113
PMCID: PMC5644842
PMID: 24903324
Abstract
This study examined the heterogeneity in BMI development by identifying distinct developmental trajectories. These trajectories were further investigated by relating them to markers of low-grade inflammation later in life. Data from approximately 400 healthy volunteers participating in the Spokane Heart Study were collected in 2-year intervals, and four waves of data were available for the current analyses. Body weight was measured by BMI and low-grade inflammation by high-sensitivity C-reactive protein (CRP) and fibrinogen. Up to date statistical techniques, i.e. latent class growth models, were used to analyse heterogeneity in body weight, and linear regressions were run to analyse possible associations between trajectories of body weight and CRP/fibrinogen levels. Six trajectories were identified (three stable, two increasing, and one decreasing) which differed significantly on CRP/fibrinogen levels, highlighting the importance of weight trajectories. The differences were only partly explained by variations in lifestyle habits.
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Details
- Title
- Effects of Long-Term Developmental Patterns of Adiposity on Levels of C-Reactive Protein and Fibrinogen among North-American Men and Women: The Spokane Heart Study
- Creators
- Trynke HoekstraCelestina Barbosa-LeikerBruce R WrightJos W.R Twisk
- Publication Details
- Obesity facts, Vol.7(3), pp.197-210
- Academic Unit
- Nursing, College of
- Publisher
- S. Karger GmbH; Wilhelmstrasse 20A, P.O. Box · Postfach · Case postale, D–79095, Freiburg, Germany · Deutschland · Allemagne, Phone: +49 761 45 20 70, Fax: +49 761 4 52 07 14, information@karger.de
- Identifiers
- 99900546523401842
- Language
- English
- Resource Type
- Journal article