Journal article
Effects of MgO‐CaO‐P2O5‐Na2O‐based additives on mechanical and biological properties of hydroxyapatite
Journal of biomedical materials research. Part A, Vol.71A(1), pp.35-44
10/01/2004
Handle:
https://hdl.handle.net/2376/103820
PMID: 15368252
Abstract
In this research, we improved densification, hardness, and compression strength of synthetic hydroxyapatite (HAp) ceramics by introducing small quantities of MgO‐CaO‐P2O5‐Na2O‐based sintering additives. Biological properties of HAp were not altered by this procedure. Phase analyses were performed by using a Philips Xpert fully automated diffractometer with Co K‐alpha radiation to understand the influence of additives on phase purity in the final products. All compositions were characterized at green and sintered densities to understand the influence of additives on densification. Some of the compositions showed >40% increase in Vickers microhardness compared with pure HAp processed under the same conditions. Improvement in compression strength was also detected in some compositions. In vitro biological testing used a modified human osteoblast cell line to test biocompatibility, cell attachment, and cell proliferation. All these compositions were nontoxic and biocompatible. Our results indicate that MgO‐CaO‐P2O5‐Na2O‐based sintering additives can be used to improve both mechanical and biological properties of HAp ceramics. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 35–44, 2004
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Details
- Title
- Effects of MgO‐CaO‐P2O5‐Na2O‐based additives on mechanical and biological properties of hydroxyapatite
- Creators
- S. J KalitaD RokusekS BoseH. L HosickA Bandyopadhyay
- Publication Details
- Journal of biomedical materials research. Part A, Vol.71A(1), pp.35-44
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- Number of pages
- 10
- Grant note
- National Science Foundation (CAREER grant DMI 9874971)
- Identifiers
- 99900546663601842
- Language
- English
- Resource Type
- Journal article