Journal article
Effects of atropine on respiratory sinus arrhythmia (RSA) in the rhesus macaque
Neurotoxicology and teratology, Vol.10(2), pp.169-174
1988
Handle:
https://hdl.handle.net/2376/108496
PMID: 3398825
Abstract
Twelve juvenile to adult rhesus macaques were administered atropine sulfate (0, 14, 44, and 140 mcg/kg IM). The amplitude of the respiratory sinus arrhythmia (RSA) in the rhesus macaque was estimated using a Vagal Tone Monitor (VTM). The estimate of RSA (termed V; vagal tone) was significantly reduced for nearly 3 hr after all doses of atropine, suggesting possible central nervous system effects. Heart period (R-R interval) was reduced briefly after dosing. Overall heart period variability (HPV) was depressed after all doses of atropine. The amount of atropine required to decrease HPV and V by 30% was similar to that reported for the human. The rhesus monkey was determined to have little resting vagal tone as estimated by V. A large slow wave oscillation contributed to the overall variability in heart period. It is concluded that the rhesus monkey exhibits a similar sensitivity to atropine as did the human and, therefore, provides a useful model for the study of cholinergic drug actions and their effects on RSA.
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Details
- Title
- Effects of atropine on respiratory sinus arrhythmia (RSA) in the rhesus macaque
- Creators
- H.T JansenJ.A Dellinger
- Publication Details
- Neurotoxicology and teratology, Vol.10(2), pp.169-174
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547061301842
- Language
- English
- Resource Type
- Journal article