Journal article
Effects of dexamethasone on cell-mediated immune responses in cattle sensitized to Mycobacterium bovis
American journal of veterinary research, Vol.56(10), pp.1300-1306
10/1995
Handle:
https://hdl.handle.net/2376/115120
PMID: 8928946
Abstract
Systemic administration of dexamethasone led to a significant reduction in the size of the tuberculin reaction in response to intradermal injection of bovine purified protein derivative in 18 cattle experimentally sensitized to Mycobacterium bovis (P < 0.01) and 8 cattle naturally infected with M bovis (P < 0.001). The reaction in 6 of the 7 M bovis infected cattle that received dexamethasone was classified as negative for the standard interpretation of the single intradermal comparative tuberculin test. Significantly fewer BoCD2+ (P < 0.05) and BoCD4+ T cells (P < 0.001) were present at the reaction site and in blood of dexamethasone-treated cattle, compared with untreated control cattle. Significantly fewer cells expressing the interleukin-2 receptor and WC1+ gamma delta T cells (P < 0.001), and a significantly greater number of cells expressing the ACT2 antigen (P < 0.05) were found at the reaction site in dexamethasone treated cattle than in controls. The number of BoCD8+ T cells at the reaction site and in blood was not significantly affected by administration of dexamethasone. In vitro production of interferon-gamma by lymphocytes incubated with bovine purified protein derivative also was significantly lower (P < 0.01) in the dexamethasone treated cattle.
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Details
- Title
- Effects of dexamethasone on cell-mediated immune responses in cattle sensitized to Mycobacterium bovis
- Creators
- M L Doherty - Faculty of Veterinary Medicine, University College Dublin, Ballsbridge, IrelandH F BassettP J QuinnW C DavisM L Monaghan
- Publication Details
- American journal of veterinary research, Vol.56(10), pp.1300-1306
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- United States
- Identifiers
- 99900547734701842
- Language
- English
- Resource Type
- Journal article