Effects of dietary cholesterol and its oxidation products on pathological lesions and cholesterol and lipid oxidation in the rabbit liver

Sun Jin Hur; Ki Chang Nam; Byungrok Min; Min Du; Kwon Il Seo; Dong Uk Ahn

doi:10.1155/2014/598612

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Effects of dietary cholesterol and its oxidation products on pathological lesions and cholesterol and lipid oxidation in the rabbit liver

Journal article

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Effects of dietary cholesterol and its oxidation products on pathological lesions and cholesterol and lipid oxidation in the rabbit liver

Sun Jin Hur, Ki Chang Nam, Byungrok Min, Min Du, Kwon Il Seo and Dong Uk Ahn

BioMed research international, Vol.2014, pp.598612-7

2014

DOI: https://doi.org/10.1155/2014/598612

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https://hdl.handle.net/2376/113729

PMCID: PMC3950612

PMID: 24696857

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Abstract

Rabbits

Liver - pathology

Animals

Liver - drug effects

Cholesterol, Dietary - pharmacology

Liver - metabolism

Lipid Metabolism - drug effects

Oxidation-Reduction - drug effects

Male

Thiobarbituric Acid Reactive Substances - metabolism

Fatty Acids - metabolism

This study was conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxidation products (COPs) on the induction of pathological lesions in rabbit liver tissues. Liver lesions were induced only when the levels of CHO and COPs in the diet were very high. The amount of CHO measured in the liver increased when dietary CHO was increased; by comparison, dietary COPs affected liver CHO amounts to a lesser extent. The TBARS (thiobarbituric acid reactive substances) value measured for the liver samples also increased when dietary CHO and COP levels were elevated, and the TBARS value was more strongly affected by the amount of COPs in the diet than by the amount of CHO. At 6 and 12 weeks, COP levels were the highest in the group that received 1.2 g CHO + 0.8 g COPs, followed by the 0.5 g CHO + 0.5 g COPs and 1.6 g CHO + 0.4 g COPs groups; the control (0 g) group showed the lowest COP levels among all groups. In this study, we found that not only dietary CHO but also COPs were involved in hypercholesterolemia induced liver lesions when the amount of CHO and COPs was high.

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Title: Effects of dietary cholesterol and its oxidation products on pathological lesions and cholesterol and lipid oxidation in the rabbit liver
Creators: Sun Jin Hur - Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi-do 456-756, Republic of Korea
Ki Chang Nam - Department of Animal Science and Technology, Sunchon National University, Suncheon 540-742, Republic of Korea
Byungrok Min - Food Science and Technology Program, Department of Agriculture, Food, and Resource Sciences, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
Min Du - Department of Animal Science, Washington State University, Pullman, WA 99164-6310, USA
Kwon Il Seo - Department of Food and Nutrition, Sunchon National University, Suncheon 540-742, Republic of Korea
Dong Uk Ahn - Department of Animal Science and Technology, Sunchon National University, Suncheon 540-742, Republic of Korea ; Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50011, USA
Publication Details: BioMed research international, Vol.2014, pp.598612-7
Academic Unit: Animal Sciences, Department of
Publisher: United States
Identifiers: 99900547409201842
Language: English
Resource Type: Journal article