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Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever
Journal article   Peer reviewed

Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever

Shai Shoham, Clark M Blatteis and James M Krueger
Brain research, Vol.476(2), pp.396-399
1989
Handle:
https://hdl.handle.net/2376/117917
PMID: 2702477

Abstract

Muramyl dipeptide Slow-wave sleep Electroencephalogram Rabbit Hypothalamus Rapid eye movement sleep Hyperthermia Fever
Lesions of the preoptic area of rabbits caused hyperthermia, although they did not alter sleep-coupled changes in brain temperature, and reduced slow-wave sleep, rapid eye movement sleep, and amplitudes of electroencephalographic slow waves during slow wave sleep. The direction and magnitude of the muramyl dipeptide-induced responses were similar before and after the lesions, although the baseline values upon which the changes were superimposed had shifted.

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