Journal article
Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains
Alcohol (Fayetteville, N.Y.), Vol.44(6), pp.487-493
2010
Handle:
https://hdl.handle.net/2376/106326
PMCID: PMC2954060
PMID: 20705420
Abstract
Depressive symptoms in alcohol-dependent individuals are well-recognized and clinically relevant phenomena. The etiology has not been elucidated although it is clear that the depressive symptoms may be alcohol independent or alcohol induced. To contribute to the understanding of the neurobiology of chronic ethanol use, we investigated the effects of chronic intermittent ethanol vapor exposure on behaviors in the forced swim test (FST) and neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) levels in specific brain regions. Adult male Wistar rats were subjected to intermittent ethanol vapor (14
h on/10
h off) or air exposure for 2 weeks and were then tested at three time points corresponding to acute withdrawal (8–12
h into withdrawal) and protracted withdrawal (30 and 60 days of withdrawal) in the FST. The behaviors that were measured in the five-min FST consisted of latency to immobility, swim time, immobility time, and climbing time. The FST results showed that the vapor-exposed animals displayed depressive-like behaviors; for instance, decreased latency to immobility in acute withdrawal and decreased latency to immobility, decreased swim time and increased immobility time in protracted withdrawal, with differences between air- and vapor-exposed animals becoming more pronounced over the 60-day withdrawal period. NPY levels in the frontal cortex of the vapor-exposed animals were decreased compared with the control animals, and CRF levels in the amygdala were correlated with increased immobility time. Thus, extended ethanol vapor exposure produced long-lasting changes in FST behavior and NPY levels in the brain.
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Details
- Title
- Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains
- Creators
- Brendan M Walker - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USADavid A Drimmer - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USAJennifer L Walker - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USATianmin Liu - Karolinska Institute, Department of Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, Stockholm, SwedenAleksander A Mathé - Karolinska Institute, Department of Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, Stockholm, SwedenCindy L Ehlers - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
- Publication Details
- Alcohol (Fayetteville, N.Y.), Vol.44(6), pp.487-493
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546606801842
- Language
- English
- Resource Type
- Journal article