Journal article
Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)
Journal of applied physiology (1985), Vol.84(1), pp.69-76
01/01/1998
Handle:
https://hdl.handle.net/2376/105465
PMID: 9451619
Abstract
Swallow, John G., Theodore Garland, Jr., Patrick A. Carter, Wen-Zhi Zhan, and Gary C. Sieck. Effects of voluntary activity and genetic selection on aerobic capacity in house mice ( Mus domesticus). J. Appl. Physiol. 84(1): 69–76, 1998.—An animal model was developed to study effects on components of exercise physiology of both “nature” (10 generations of genetic selection for high voluntary activity on running wheels) and “nurture” (7–8 wk of access or no access to running wheels, beginning at weaning). At the end of the experiment, mice from both wheel-access groups were significantly lighter in body mass than mice from sedentary groups. Within the wheel-access group, a statistically significant, negative relationship existed between activity and final body mass. In measurements of maximum oxygen consumption during forced treadmill exercise (V˙o 2 max), mice with wheel access were significantly more cooperative than sedentary mice; however, trial quality was not a significant predictor of individual variation in V˙o 2 max. Nested two-way analysis of covariance demonstrated that both genetic selection history and access to wheels had significant positive effects on V˙o 2 max. A 12% difference inV˙o 2 max existed between wheel-access selected mice, which had the highest mass-correctedV˙o 2 max, and sedentary control mice, which had the lowest. The respiratory exchange ratio at V˙o 2 max was also significantly lower in the wheel-access group. Our results suggest the existence of a possible genetic correlation between voluntary activity levels (behavior) and aerobic capacity (physiology).
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Details
- Title
- Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)
- Creators
- John G Swallow - Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706-1381; andTheodore Garland - Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706-1381; andPatrick A Carter - Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706-1381; andWen-Zhi Zhan - Departments of Anesthesiology, Physiology, and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905Gary C Sieck - Departments of Anesthesiology, Physiology, and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905
- Publication Details
- Journal of applied physiology (1985), Vol.84(1), pp.69-76
- Academic Unit
- Biological Sciences, School of
- Identifiers
- 99900546626801842
- Language
- English
- Resource Type
- Journal article