Journal article
Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens
Proceedings of the National Academy of Sciences - PNAS, Vol.98(7), pp.4130-4135
03/27/2001
Handle:
https://hdl.handle.net/2376/108557
PMCID: PMC31191
PMID: 11274438
Abstract
Ehrlichiae are responsible for important tick-transmitted diseases,
including anaplasmosis, the most prevalent tick-borne infection of
livestock worldwide, and the emerging human diseases monocytic and
granulocytic ehrlichiosis. Antigenic variation of major surface
proteins is a key feature of these pathogens that allows persistence in
the mammalian host, a requisite for subsequent tick transmission. In
Anaplasma marginale
pseudogenes for two antigenically
variable gene families,
msp
2 and
msp
3,
appear in concert. These pseudogenes can be recombined into the
functional expression site to generate new antigenic variants.
Coordinated control of the recombination of these genes would allow
these two gene families to act synergistically to evade the host immune
response.
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Details
- Title
- Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens
- Creators
- Kelly A Brayton - Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040; andDonald P Knowles - Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040; andTravis C McGuire - Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040; andGuy H Palmer - Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040; and
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.98(7), pp.4130-4135
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- The National Academy of Sciences
- Identifiers
- 99900547617701842
- Language
- English
- Resource Type
- Journal article