Journal article
Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors
Bioorganic & medicinal chemistry letters, Vol.12(11), pp.1507-1510
06/03/2002
Handle:
https://hdl.handle.net/2376/103223
PMID: 12031330
Abstract
The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).
Metrics
2 Record Views
Details
- Title
- Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors
- Creators
- Tingwei Cai - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAMing XianPeng George Wang
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.12(11), pp.1507-1510
- Academic Unit
- Chemistry, Department of
- Publisher
- England
- Grant note
- GM 54074 / NIGMS NIH HHS
- Identifiers
- 99900546633901842
- Language
- English
- Resource Type
- Journal article