Journal article
Electrospray ionization with ambient pressure ion mobility separation and mass analysis by orthogonal time‐of‐flight mass spectrometry
Rapid communications in mass spectrometry, Vol.15(23), pp.2221-2226
12/15/2001
Handle:
https://hdl.handle.net/2376/116591
PMID: 11746889
Abstract
Rapid screening and identification of drug and other mixtures are possible using a novel ambient pressure high‐resolution ion mobility (APIMS) orthogonal reflector time‐of‐flight mass spectrometer (TOFMS). Departing ions from the APIMS drift tube traversed a pressure interface between the APIMS and TOFMS where they were subjected to numerous gas collisions that could produce selective fragmentation. By increasing the accelerating field in the pressure interface region, the ions generated using water‐cooled electrospray ionization (ESI) underwent collision‐induced dissociation (CID). Mixtures of ESI ions were separated by APIMS based on their respective size‐to‐charge (s/z) ratios while CID and analysis of mass‐to‐charge (m/z) ratios occurred in the pressure interface and TOFMS. Product ions that were formed in this pressure interface region could be readily assigned to precursor ions by matching the mobility drift times. This process was demonstrated by the examination of a mixture of amphetamines and the resulting fragmentation patterns of the mobility‐separated precursor ion species [M + H]+. Copyright © 2001 John Wiley & Sons, Ltd.
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Details
- Title
- Electrospray ionization with ambient pressure ion mobility separation and mass analysis by orthogonal time‐of‐flight mass spectrometry
- Creators
- Wes E SteinerBrian H ClowersKatrin FuhrerMarc GoninLaura M MatzWilliam F SiemsAlbert J SchultzHerbert H Hill
- Publication Details
- Rapid communications in mass spectrometry, Vol.15(23), pp.2221-2226
- Academic Unit
- Chemistry, Department of
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 6
- Grant note
- INEEL US Army Research Office (DAAG 559810107 and DAAD 190010028)
- Identifiers
- 99900548153501842
- Language
- English
- Resource Type
- Journal article