Journal article
Emerging roles of zinc finger proteins in regulating adipogenesis
Cellular and molecular life sciences : CMLS, Vol.70(23), pp.4569-4584
12/2013
Handle:
https://hdl.handle.net/2376/107559
PMCID: PMC4100687
PMID: 23760207
Abstract
Proteins containing the zinc finger domain(s) are named zinc finger proteins (ZFPs), which are one of the largest classes of transcription factors in eukaryotic genomes. A large number of ZFPs have been studied and many of them were found to be involved regulating normal growth and development of cells and tissues through diverse signal transduction pathways. Recent studies revealed that a small but increasing number of ZFPs could function as key transcriptional regulators involved in adipogenesis. As the prevalence of obesity and metabolic disorders, the investigation of molecular regulatory mechanisms of adipocyte development must be more completely understood to develop novel and long term impact strategies for ameliorating obesity. In this review, we discuss recent work which has documented that ZFPs are important functional contributors to the regulation of adipogenesis. Taken altogether these data lead to the conclusion that ZFPs may become promising targets to combat human obesity.
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Details
- Title
- Emerging roles of zinc finger proteins in regulating adipogenesis
- Creators
- Shengjuan Wei - College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P R ChinaLifan Zhang - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, P R ChinaXiang Zhou - Department of Animal Sciences, Washington State University, Pullman, WA 99164, USAMin Du - Department of Animal Sciences, Washington State University, Pullman, WA 99164, USAZhihua Jiang - Department of Animal Sciences, Washington State University, Pullman, WA 99164, USAGary J Hausman - Animal Science Department, University of Georgia, Athens, GA 30602-2771, USAWerner G Bergen - Program in Cellular and Molecular Biosciences/Department of Animal Sciences, Auburn University, Auburn, AL 36849, USALinsen Zan - College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P R ChinaMichael V Dodson - Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Cellular and molecular life sciences : CMLS, Vol.70(23), pp.4569-4584
- Academic Unit
- Animal Sciences, Department of
- Identifiers
- 99900546711801842
- Language
- English
- Resource Type
- Journal article