Journal article
Endocrine disruptors and epigenetic transgenerational disease etiology
Pediatric research, Vol.61(5 Pt 2), pp.48R-50R
05/2007
Handle:
https://hdl.handle.net/2376/113676
PMCID: PMC5940327
PMID: 17413841
Abstract
Exposure to an environmental factor (e.g. endocrine disruptor) during embryonic gonadal sex determination appears to be epigenetically reprogram the male germ-line and subsequently promote transgenerational adult-onset disease. Disease phenotypes resulting from this epigenetic phenomenon include testis abnormalities, prostate disease, kidney disease, tumor development, and immune abnormalities. The epigenetic mechanism is hypothesized to involve the induction of new imprinted-like DNA sequences in the germ-line to transgenerationally transmit disease phenotypes. This epigenetic transgenerational disease mechanism provides a unique perspective from which to view adult onset disease and ultimately offers new insights into novel diagnostic and therapeutic strategies.
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Details
- Title
- Endocrine disruptors and epigenetic transgenerational disease etiology
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA. skinner@mail.wsu.edu
- Publication Details
- Pediatric research, Vol.61(5 Pt 2), pp.48R-50R
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900548112401842
- Language
- English
- Resource Type
- Journal article