Journal article
Enhancement of slow-wave sleep by endotoxin and lipid A
The American journal of physiology, Vol.251(3 Pt 2), pp.R591-597
09/1986
Handle:
https://hdl.handle.net/2376/106423
PMID: 3529990
Abstract
Some muramyl peptides derived from bacterial peptidoglycan enhance slow-wave sleep (SWS). The purpose of this study was to test whether another cell wall component, lipopolysaccharide (LPS), and its lipid A moiety also have an effect on sleep. When injected intravenously, both LPS and lipid A enhanced the duration of SWS, increased electroencephalogram delta-wave amplitudes, suppressed rapid eye movement (REM) sleep, and induced biphasic fevers. The effects of intravenously administered lipid A and LPS on SWS were present primarily during the first 3 h postinjection. Intraventricular lipid A administration enhanced SWS, did not suppress REM, and induced a monophasic fever; the SWS effect had a 3-h latency, whereas temperature started to rise during the second hour. Regardless of the route of administration, within the dose range used here, sleep was normal by the following criteria: sleep was episodic, animals could be easily aroused, and brain temperature, although elevated to "febrile" levels, continued to fluctuate during sleep-state transitions indistinguishably from control conditions. We conclude that LPS and lipid A are capable of modulating sleep.
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Details
- Title
- Enhancement of slow-wave sleep by endotoxin and lipid A
- Creators
- J M KruegerS KubillusS ShohamD Davenne
- Publication Details
- The American journal of physiology, Vol.251(3 Pt 2), pp.R591-597
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- GM-36280 / NIGMS NIH HHS
- Identifiers
- 99900547495501842
- Language
- English
- Resource Type
- Journal article