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CC BY V4.0, Open Access
Journal article
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability
Epigenetics, Vol.6(7), pp.838-842
07/2011
Handle:
https://hdl.handle.net/2376/111301
PMCID: PMC5703187
PMID: 21637037
Abstract
The majority of environmental factors can not modify DNA sequence, but can influence the epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics to influence phenotypic variation and disease, suggests environmental epigenetics will have a critical role in disease etiology and biological areas such as evolutionary biology. The current review presents the molecular basis of how environment can promote stable epigenomes and modified phenotypes, and distinguishes the difference between epigenetic transgenerational inheritance through the germ line versus somatic cell mitotic stability.
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Details
- Title
- Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA. skinner@wsu.edu
- Publication Details
- Epigenetics, Vol.6(7), pp.838-842
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900548580701842
- Language
- English
- Resource Type
- Journal article