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CC BY V4.0, Open Access
Journal article
Environmental stress and epigenetic transgenerational inheritance
BMC medicine, Vol.12(1), pp.153-153
09/05/2014
Handle:
https://hdl.handle.net/2376/107461
PMCID: PMC4244059
PMID: 25259699
Abstract
Previous studies have shown a wide variety of environmental toxicants and abnormal nutrition can promote the epigenetic transgenerational inheritance of disease. More recently a number of studies have indicated environmental stress can also promote epigenetic alterations that are transmitted to subsequent generations to induce pathologies. A recent study by Yao and colleagues demonstrated gestational exposure to restraint stress and forced swimming promoted preterm birth risk and adverse newborn outcomes generationally. This ancestral stress promoted the epigenetic transgenerational inheritance of abnormalities in the great-grand offspring of the exposed gestating female. Several studies now support the role of environmental stress in promoting the epigenetic transgenerational inheritance of disease. Observations suggest ancestral environmental stress may be a component of disease etiology in the current population.
Please see related article:
http://www.biomedcentral.com/content/pdf/s12916-014-0121-6.pdf
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Details
- Title
- Environmental stress and epigenetic transgenerational inheritance
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236 USA
- Publication Details
- BMC medicine, Vol.12(1), pp.153-153
- Academic Unit
- Biological Sciences, School of
- Publisher
- BioMed Central; London
- Identifiers
- 99900547381001842
- Language
- English
- Resource Type
- Journal article