Journal article
Environmentally induced antinociception and hyperalgesia in rats and mice
Brain research, Vol.1415, pp.56-62
09/30/2011
Handle:
https://hdl.handle.net/2376/111566
PMID: 21880302
Abstract
Stress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately after removal from the maze. Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze. This hyperalgesia occurred with or without the added stress of a hind paw formalin injection and regardless of whether rats were exposed to an EPM with open (oEPM) or enclosed (eEPM) arms despite a clear antinociceptive effect while on the oEPM. Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM. These data demonstrate that a mild stressor such as the EPM can produce both antinociception and hyperalgesia depending on the context. This shift from antinociception to hyperalgesia occurs rapidly and is evident in mice, male and female rats, and with the hot plate and formalin tests.
► Rats display hyperalgesia on the hot plate immediately after exposure to the EPM. ► This hyperalgesia is probably caused by the stress associated with novelty. ► Fear-induced antinociception is present only during exposure to the EPM. ► Mice removed from the EPM display a shift from antinociception to normal nociception.
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Details
- Title
- Environmentally induced antinociception and hyperalgesia in rats and mice
- Creators
- Alianda Maira Cornélio - Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas, UFSCar-UNESP, Rod. Araraquara-Jaú, km 01, 14801-902 Araraquara, SP, BrazilJoyce Mendes-Gomes - Programa de Pós-Graduação em Psicobiologia, FFCLRP-USP, AV. Bandeirantes 3900, 14040-901, Ribeirão Preto, SP, BrazilJuliana Sayuri Fugimoto - Lab. Farmacologia, Faculdade de Ciências Farmacêuticas, UNESP, Rod. Araraquara-Jaú, km 01, 14801-902 Araraquara, SP, BrazilMichael M Morgan - Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave., Vancouver, WA 98686, USARicardo Luiz Nunes-de-Souza - Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas, UFSCar-UNESP, Rod. Araraquara-Jaú, km 01, 14801-902 Araraquara, SP, Brazil
- Publication Details
- Brain research, Vol.1415, pp.56-62
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547694901842
- Language
- English
- Resource Type
- Journal article