Epigenetic programming of the germ line: Effects of endocrine disruptors on the development of transgenerational disease

Matthew D Anway; Michael K Skinner

doi:10.1016/S1472-6483(10)60553-6

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Epigenetic programming of the germ line: Effects of endocrine disruptors on the development of transgenerational disease

Journal article

Open access

Peer reviewed

Epigenetic programming of the germ line: Effects of endocrine disruptors on the development of transgenerational disease

Matthew D Anway and Michael K Skinner

Reproductive biomedicine online, Vol.16(1), pp.23-25

2008

DOI: https://doi.org/10.1016/S1472-6483(10)60553-6

Handle:

https://hdl.handle.net/2376/109176

PMID: 18252044

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Abstract

germ line programming

adult onset disease

transgenerational

endocrine disruption

Epigenetics

Epigenetic programming of the germ line occurs during embryonic development in a sex-specific manner. The male germ line becomes imprinted following sex determination. Environmental influences can alter this epigenetic programming and affect not only the developing offspring, but also potentially subsequent generations. Exposure to an endocrine disruptor (i.e. vinclozolin) during embryonic gonadal sex determination can alter the male germ-line epigenetics (e.g. DNA methylation). The epigenetic mechanism involves the alteration of DNA methylation in the germ line that appears to transmit transgenerational adult onset disease, including spermatogenic defects, prostate disease, kidney disease and cancer.

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Details

Title: Epigenetic programming of the germ line
Creators: Matthew D Anway
Michael K Skinner
Publication Details: Reproductive biomedicine online, Vol.16(1), pp.23-25
Academic Unit: Biological Sciences, School of
Publisher: Elsevier Ltd
Identifiers: 99900547162301842
Language: English
Resource Type: Journal article