Journal article
Epigenetic transgenerational actions of endocrine disruptors and male fertility
Science (American Association for the Advancement of Science), Vol.308(5727), pp.1466-1469
06/03/2005
Handle:
https://hdl.handle.net/2376/102647
PMID: 15933200
Abstract
Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility. These effects were transferred through the male germ line to nearly all males of all subsequent generations examined (that is, F1 to F4). The effects on reproduction correlate with altered DNA methylation patterns in the germ line. The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.
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Details
- Title
- Epigenetic transgenerational actions of endocrine disruptors and male fertility
- Creators
- Matthew D Anway - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USAAndrea S CuppMehmet UzumcuMichael K Skinner
- Publication Details
- Science (American Association for the Advancement of Science), Vol.308(5727), pp.1466-1469
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Identifiers
- 99900546697601842
- Language
- English
- Resource Type
- Journal article