Journal article
Epigenetic transgenerational actions of endocrine disruptors
Endocrinology (Philadelphia), Vol.147(6 Suppl), pp.S43-s49
06/2006
Handle:
https://hdl.handle.net/2376/116742
PMID: 16690803
Abstract
Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male infertility). The anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic sex determination to promote in the F1 generation a spermatogenic cell defect and subfertility in the male. When the animals were allowed to age up to 1 yr, a number of other disease states developed. This phenotype was transferred through the male germ line to all subsequent generations analyzed (F1-F4). The ability of an environmental factor (i.e. endocrine disruptor) to promote an epigenetic transgenerational phenotype impacts the potential hazards of environmental toxins, mechanisms of disease etiology, and evolutionary biology. The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes.
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Details
- Title
- Epigenetic transgenerational actions of endocrine disruptors
- Creators
- Matthew D Anway - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USAMichael K Skinner
- Publication Details
- Endocrinology (Philadelphia), Vol.147(6 Suppl), pp.S43-s49
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900548480501842
- Language
- English
- Resource Type
- Journal article