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CC BY-NC V4.0, Open Access
Journal article
Epigenetic transgenerational inheritance, gametogenesis and germline development
Biology of reproduction, Vol.105(3), pp.570-592
09/14/2021
PMCID: PMC8444706
PMID: 33929020
Abstract
One of the most important developing cell types in any biological system is the gamete (sperm and egg). The transmission of phenotypes and optimally adapted physiology to subsequent generations is in large part controlled by gametogenesis. In contrast to genetics, the environment actively regulates epigenetics to impact the physiology and phenotype of cellular and biological systems. The integration of epigenetics and genetics is critical for all developmental biology systems at the cellular and organism level. The current review is focused on the role of epigenetics during gametogenesis for both the spermatogenesis system in the male and oogenesis system in the female. The developmental stages from the initial primordial germ cell through gametogenesis to the mature sperm and egg are presented. How environmental factors can influence the epigenetics of gametogenesis to impact the epigenetic transgenerational inheritance of phenotypic and physiological change in subsequent generations is reviewed.
Summary sentence
How environmental factors can influence the epigenetics of gametogenesis to impact the epigenetic transgenerational inheritance of phenotypic and physiological change in subsequent generations is reviewed.
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Details
- Title
- Epigenetic transgenerational inheritance, gametogenesis and germline development
- Creators
- Millissia Ben Maamar - Washington State UniversityEric E. Nilsson - Washington State UniversityMichael K. Skinner - Washington State University
- Publication Details
- Biology of reproduction, Vol.105(3), pp.570-592
- Academic Unit
- Biological Sciences, School of
- Publisher
- Oxford Univ Press
- Number of pages
- 23
- Grant note
- 50183; 61174 / John Templeton Foundation ES012974 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Identifiers
- 99901080824201842
- Language
- English
- Resource Type
- Journal article