Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis

Gary Craig; Howard Kenney; Eric E Nilsson; Ingrid Sadler-Riggleman; Daniel Beck; Michael K Skinner

doi:10.1038/s41598-021-03170-6

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Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis

Journal article

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Peer reviewed

Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis

Gary Craig, Howard Kenney, Eric E Nilsson, Ingrid Sadler-Riggleman, Daniel Beck and Michael K Skinner

Scientific reports, Vol.11(1), pp.23789-23789

12/10/2021

DOI: https://doi.org/10.1038/s41598-021-03170-6

PMCID: PMC8664902

PMID: 34893669

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Abstract

Arthritis, Rheumatoid - etiology

Autoimmunity - genetics

Computational Biology - methods

Disease Susceptibility

DNA Methylation

Epigenesis, Genetic

Epigenomics - methods

Gene Expression Profiling

Gene Expression Regulation

Gene Regulatory Networks

Monocytes - immunology

Monocytes - metabolism

Mouth Mucosa - immunology

Mouth Mucosa - metabolism

Sex Factors

Biomarkers

Genetics (i.e., mutations) has been assumed to be the major factor in rheumatoid arthritis (RA) etiology, but accounts for a minority of the variance in disease risk for RA. In contrast to genetics, the environment can have dramatic impacts on epigenetics that associate with disease etiology. The current study used buccal cells and purified blood monocytes from two different clinical cohorts involving Caucasian or African American female populations with or without arthritis. The differential DNA methylation regions (DMRs) between the control and RA populations were identified with an epigenome-wide association study. The DMRs (i.e., epimutations) identified in the buccal cells and monocytes were found to be distinct. The DMR associated genes were identified and many have previously been shown to be associated with arthritis. Observations demonstrate DNA methylation epimutation RA biomarkers are cell type specific and similar findings were observed with the two racial background populations. Rheumatoid arthritis susceptibility epigenetic diagnosis appears feasible and may improve the clinical management of RA and allowpreventative medicine considerations.

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Title: Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis
Creators: Gary Craig - Arthritis Northwest
Howard Kenney - Arthritis Northwest
Eric E Nilsson - Washington State University
Ingrid Sadler-Riggleman - Washington State University
Daniel Beck - Washington State University
Michael K Skinner - Washington State University
Publication Details: Scientific reports, Vol.11(1), pp.23789-23789
Academic Unit: Biological Sciences, School of
Identifiers: 99901080814501842
Language: English
Resource Type: Journal article