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Epigenome-wide association study of systemic effects of obesity susceptibility in human twins4.27 MB
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Journal article
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins
Epigenetics, Vol.18(1), pp.2268834-2268834
12/31/2023
PMID: 37871278
Abstract
The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant twin pairs. Buccal cells (from a cheek swab) were used as a non-obesity relevant purified marker cell for the epigenetic analysis. Analysis of differential DNA methylation regions (DMRs) was used to identify epigenetic associations with metabolic and dietary measures related to obesity with discordant twins. An edgeR analysis provided a DMR signature with p < 1e-04, but statistical significance was reduced due to low sample size and known multiple origins of obesity. A weighted gene coexpression network analysis (WGCNA) was performed and identified modules (p < 0.005) of epigenetic sites that correlated with different metabolic and dietary measures. The DMR and WGCNA epigenetic sites were near genes (e.g., CIDEC, SPP1, ZFPG9, and POMC) with previously identified obesity associated pathways (e.g., metabolism, cholesterol, and fat digestion). Observations demonstrate the feasibility of identifying systemic epigenetic biomarkers for obesity, which can be further investigated for clinical relevance in future research with larger sample sizes. The availability of a systemic epigenetic biomarker for obesity susceptibility may facilitate preventative medicine and clinical management of the disease early in life.
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Details
- Title
- Epigenome-wide association study of systemic effects of obesity susceptibility in human twins
- Creators
- Glen E. Duncan - Washington State UniversityAlly Avery - Washington State UniversityMillissia Ben Maamar - Washington State Univ, Ctr Reprod Biol, Sch Biol Sci, Pullman, WA USAEric E. Nilsson - Washington State UniversityDaniel Beck - Washington State UniversityMichael K. Skinner - Washington State University
- Publication Details
- Epigenetics, Vol.18(1), pp.2268834-2268834
- Academic Unit
- Biological Sciences, School of
- Publisher
- Taylor & Francis
- Number of pages
- 18
- Grant note
- We acknowledge Ms Shelby Tarutis at the Washington State Twin Registry for twin recruitment and sample collection assistance, and we thank the twins who participated in this study. We acknowledge Dr Jennifer L.M. Thorson, Ms Alexandra Korolenko, and Mr Gra
- Identifiers
- 99901080307101842
- Language
- English
- Resource Type
- Journal article