Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype

Jong Y Park; Stimson P Schantz; Philip Lazarus

doi:10.1016/S1368-8375(03)00008-3

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Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype

Journal article

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Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype

Jong Y Park, Stimson P Schantz and Philip Lazarus

Oral oncology, Vol.39(5), pp.483-490

07/2003

DOI: https://doi.org/10.1016/S1368-8375(03)00008-3

Handle:

https://hdl.handle.net/2376/115826

PMCID: PMC3715071

PMID: 12747973

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https://doi.org/10.1016/S1368-8375(03)00008-3View

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Abstract

Cancer susceptibility

Orolaryngeal cancer

Glutathione S-transferase

Epoxide hydrolase

Genetic polymorphism

The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles which are associated with altered EH activity and may be linked to increased risk for tobacco-related cancers. The objective was to examine the role of EH polymorphisms in orolaryngeal cancer risk. The prevalence of the EH codons 113 and 139 polymorphisms were examined in 81 African American and 142 Caucasian incident orolaryngeal cancer patients and 335 controls frequency-matched on age, sex, and race. In Caucasians, a significant risk increase was observed for subjects with the EH 113Tyr variant (OR=2.1, 95% CI=1.1–4.0) and predicted high-activity EH genotypes in heavy-smokers (≥35 pack-years; OR=3.4, 95% CI=1.2–9.6). A significant association between predicted high EH activity genotypes and orolaryngeal cancer risk was observed in Caucasian subjects with the GSTM1 null (OR=3.5, 95% CI=1.3–9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4–2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians.

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Title: Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype
Creators: Jong Y Park - Divisions of Cancer Controls and Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, 12902 Magnolia Drive, Tampa, FL 33612, USA
Stimson P Schantz - Department of Otolaryngology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
Philip Lazarus - Divisions of Cancer Controls and Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, 12902 Magnolia Drive, Tampa, FL 33612, USA
Publication Details: Oral oncology, Vol.39(5), pp.483-490
Academic Unit: Pharmaceutical Sciences, Department of
Grant note: R03 CA091314 || CA / National Cancer Institute : NCI
Identifiers: 99900548154401842
Language: English
Resource Type: Journal article