Journal article
Equilibrium and kinetics studies of transnitrosation between S -nitrosothiols and thiols
Bioorganic & medicinal chemistry letters, Vol.11(3), pp.433-436
02/2001
Handle:
https://hdl.handle.net/2376/112199
PMID: 11212129
Abstract
Using UV-vis spectrometrical measurements, equilibrium constants for NO transfer between S-nitroso-N-acetyl-penicillamine (SNAP) and different thiols as well as kinetic data for NO transfer from S-nitroso bovine serum albumin (BSANO) to thiols have been obtained. NO transfer from SNAP to other primary/secondary thiols are thermodynamically favorable, whereas other S-nitrosothiols exhibit similar NO transfer potential. The obtained Gibbs free energy, enthalpy and entropy data indicated that NO transfer reactions from SNAP to four thiols are exothermic with entropy loss. The kinetic behavior of BSANO/RSH transfer can be related to both the acidity of sulfhydryl group and the electronic structure in thiol.
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Details
- Title
- Equilibrium and kinetics studies of transnitrosation between S -nitrosothiols and thiols
- Creators
- Kun WangZhong WenWei ZhangMing XianJin-Pei ChengPeng George Wang
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.11(3), pp.433-436
- Academic Unit
- Department of Chemistry
- Identifiers
- 99900547532901842
- Language
- English
- Resource Type
- Journal article