Journal article
Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice
Experimental and clinical psychopharmacology, Vol.10(2), pp.77-83
05/2002
Handle:
https://hdl.handle.net/2376/113318
PMID: 12022801
Abstract
This study examined whether preference for a drug (diazepam or placebo) could be switched using conditioning procedures. During the first 4 sessions of Phase 1, 6 participants received 5 mg of diazepam or placebo under double-blind conditions. During the remaining 5 sessions of Phase 1, participants selected the drug they wished to receive. The first 4 sessions of Phase 2 were a replication of Phase 1, except that following ingestion of the drug, participants completed a computer task for which they could earn money. Payment for the computer task was lowest following ingestion of the drug they preferred in Phase I and highest following the drug they had avoided. Preference was reassessed during the last 5 sessions of Phase 2. Five of the participants preferred placebo in Phase 1 but diazepam in Phase 2. Subjective responses to the drugs also changed across the 2 phases.
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Details
- Title
- Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice
- Creators
- Sheila M Alessi - Department of Psychiatry and Behavioral Neurosciences, Wayne State University, USAJohn M RollMark P ReillyChris-Ellyn Johanson
- Publication Details
- Experimental and clinical psychopharmacology, Vol.10(2), pp.77-83
- Academic Unit
- Elson S. Floyd College of Medicine
- Publisher
- United States
- Grant note
- R03 DA 12592-01 / NIDA NIH HHS
- Identifiers
- 99900547509001842
- Language
- English
- Resource Type
- Journal article