Journal article
Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies
Reproductive toxicology (Elmsford, N.Y.), Vol.7(3), pp.237-248
1993
Handle:
https://hdl.handle.net/2376/106727
PMID: 8318755
Abstract
A series of studies were performed to examine the effects of various PCB congeners [3,4,3′,4′-TCB (PCB77), 2,5,2′,5′-TCB (PCB52), 4′ OH-2,4,6-TCB (OHPCB)] and a complex PCB mixtured (Aroclor 1242; A1242) on the weights and patterns of cell proliferation of immature rat uteri in vivo and the effects of A1242 on gonadotropin release by dispersed anterior pituitary cells in vitro. Immature (20-day) rats were treated ip with corn oil (vehicle), PCBs, or 17β-estradiol (E
2) once or daily for two consecutive days. Except for PCB77, all PCBs and E
2 produced significant increases in uterine weights (
P < 0.01) and increases in uterine
3H-thymidine labeling. PCB77 attenuated (
P < 0.01) the increase in uterine weight due to either A1242 or E
2 treatment. Cultured anterior pituitary cells exposed to varying concentrations of A1242 (0.1 to 50 ppm) exhibited enhanced gonadotropin responses to gonadotropin-releasing hormone (GnRH) similar to that of E
2. These results demonstrate that PCBs can produce either estrogenic
or antiestrogenic effects.
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Details
- Title
- Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies
- Creators
- Heiko T Jansen - Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USAPaul S Cooke - Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USAJohn Porcelli - Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USATsuei-Chu Liu - Department of Medical Technology, National Yang Ming Medical College, Shih-Pai, Taipei, Taiwan, Republic of ChinaLarry G Hansen - Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
- Publication Details
- Reproductive toxicology (Elmsford, N.Y.), Vol.7(3), pp.237-248
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546756401842
- Language
- English
- Resource Type
- Journal article