Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism

Michael H COURT; Soundarajan KRISHNASWAMY; QIN QIN HAO; Su. X DUAN; Christopher J PATTEN; Lisa L VON MOLTKE; David J GREENBLATT

doi:10.1124/dmd.31.9.1125

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism

Michael H COURT, Soundarajan KRISHNASWAMY, QIN QIN HAO, Su. X DUAN, Christopher J PATTEN, Lisa L VON MOLTKE and David J GREENBLATT

Drug metabolism and disposition, Vol.31(9), pp.1125-1133

2003

DOI: https://doi.org/10.1124/dmd.31.9.1125

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https://hdl.handle.net/2376/105378

PMID: 12920168

Abstract

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Analytical, structural and metabolic biochemistry

Enzymes and enzyme inhibitors

Transferases

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Title: Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism
Creators: Michael H COURT - Comparative and Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
Soundarajan KRISHNASWAMY - Comparative and Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
QIN QIN HAO - Comparative and Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
Su. X DUAN - Comparative and Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
Christopher J PATTEN - BD Gentest, Woburn, Massachusetts, United States
Lisa L VON MOLTKE - Clinical Pharmacology Laboratory , Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
David J GREENBLATT - Clinical Pharmacology Laboratory , Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts, United States
Publication Details: Drug metabolism and disposition, Vol.31(9), pp.1125-1133
Academic Unit: Veterinary Clinical Sciences, Department of
Publisher: American Society for Pharmacology and Experimental Therapeutics; Bethesda, MD
Identifiers: 99900546702001842
Language: English
Resource Type: Journal article

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B72 polymorphism

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