Journal article
Evaluation of phosphorus-containing inhibitors of γ-glutamyl hydrolase
Bioorganic & medicinal chemistry letters, Vol.8(12), pp.1521-1524
1998
Handle:
https://hdl.handle.net/2376/115637
PMID: 9873382
Abstract
Several putative, phosphorus-containing inhibitors of γ-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile.
Several putative, phosphorus-containing inhibitors of gamma-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids
3 were shown to be weak competitive inhibitors while both a phosphoramidate diester
6 and a phosphonamidate ester
4 were shown to be potent time-dependent inactivators.
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Details
- Title
- Evaluation of phosphorus-containing inhibitors of γ-glutamyl hydrolase
- Creators
- Chester E RodriguezH Michael HolmesKaryn L MlodnoskyVinh Q LamClifford E Berkman
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.8(12), pp.1521-1524
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900548206601842
- Language
- English
- Resource Type
- Journal article