Journal article
Evolution of Teleost Fish Retroviruses: Characterization of New Retroviruses with Cellular Genes
Journal of virology, Vol.83(19), pp.10152-10162
10/2009
Handle:
https://hdl.handle.net/2376/113276
PMCID: PMC2748043
PMID: 19625413
Abstract
The interactions between retroviruses and their hosts can be of a beneficial or detrimental nature. Some endogenous retroviruses are involved in development, while others cause disease. The Genome Parsing Suite (GPS) is a software tool to track and trace all Retroid agents in any sequenced genome (M. A. McClure et al., Genomics 85:512-523, 2005). Using the GPS, the retroviral content was assessed in four model teleost fish. Eleven new species of fish retroviruses are identified and characterized. The reverse transcriptase protein sequences were used to reconstruct a fish retrovirus phylogeny, thereby, significantly expanding the epsilonretrovirus family. Most of these novel retroviruses encode additional genes, some of which are homologous to cellular genes that would confer viral advantage. Although the fish divergence is much more ancient, retroviruses began infecting fish genomes approximately 4 million years ago.
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Details
- Title
- Evolution of Teleost Fish Retroviruses: Characterization of New Retroviruses with Cellular Genes
- Creators
- Holly A Basta - Department of MicrobiologySean B Cleveland - Department of MicrobiologyRochelle A Clinton - Department of MicrobiologyAlexander G Dimitrov - Department of MicrobiologyMarcella A McClure - Department of Microbiology
- Publication Details
- Journal of virology, Vol.83(19), pp.10152-10162
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- American Society for Microbiology (ASM)
- Identifiers
- 99900547674201842
- Language
- English
- Resource Type
- Journal article