Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression

C E Ogburn; K Carlberg; M A Ottinger; D J Holmes; G M Martin; S N Austad

doi:10.1093/gerona/56.11.B468

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Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression

Journal article

Open access

Peer reviewed

Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression

C E Ogburn, K Carlberg, M A Ottinger, D J Holmes, G M Martin and S N Austad

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.56(11), pp.B468-B474

11/2001

DOI: https://doi.org/10.1093/gerona/56.11.B468

Handle:

https://hdl.handle.net/2376/115299

PMID: 11682567

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Abstract

Coturnix - genetics

Coturnix - metabolism

Gene Expression - drug effects

Oxidative Stress

Species Specificity

Humans

Embryo, Mammalian - metabolism

Superoxides - toxicity

Aging - genetics

Fibroblasts - metabolism

Hydrogen Peroxide - toxicity

Cells, Cultured

Longevity - genetics

Amanitins - pharmacology

Cycloheximide - pharmacology

Biological Evolution

Parrots - metabolism

Phenotype

Animals

Embryo, Mammalian - cytology

Embryo, Nonmammalian

Mice

Parrots - genetics

Birds - metabolism

Birds - genetics

Dactinomycin - pharmacology

Longevity - physiology

Aging - metabolism

Previous studies indicated that renal tubular epithelial cells from some long-lived avian species exhibit robust and/or unique protective mechanisms against oxidative stress relative to murine cells. Here we extend these studies to investigate the response of primary embryonic fibroblast-like cells to oxidative challenge in long- and short-lived avian species (budgerigar, Melopsittacus undulatus, longevity up to 20 years, vs Japanese quail, Coturnix coturnix japonica, longevity up to 5 years) and short- and long-lived mammalian species (house mouse, Mus musculus, longevity up to 4 years vs humans, Homo sapiens, longevity up to 122 years). Under the conditions of our assay, the oxidative-damage resistance phenotype appears to be associated with exceptional longevity in avian species, but not in mammals. Furthermore, the extreme oxidative damage resistance phenotype observed in a long-lived bird requires active gene transcription and translation, suggesting that specific gene products may have evolved in long-lived birds to facilitate resistance to oxidative stress.

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Title: Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression
Creators: C E Ogburn - Department of Pathology, University of Washington, Seattle, USA
K Carlberg
M A Ottinger
D J Holmes
G M Martin
S N Austad
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.56(11), pp.B468-B474
Academic Unit: Center for Reproductive Biology
Publisher: United States
Grant note: AG01751 / NIA NIH HHS
Identifiers: 99900547823001842
Language: English
Resource Type: Journal article