Excitatory, inhibitory and facilitatory frequency response areas in the inferior colliculus of hearing impaired mice

Richard A Felix, 2nd; Christine V Portfors

doi:10.1016/j.heares.2007.02.009

Back

Excitatory, inhibitory and facilitatory frequency response areas in the inferior colliculus of hearing impaired mice

Journal article

Open access

Peer reviewed

Excitatory, inhibitory and facilitatory frequency response areas in the inferior colliculus of hearing impaired mice

Richard A Felix, 2nd and Christine V Portfors

Hearing research, Vol.228(1-2), pp.212-229

06/2007

DOI: https://doi.org/10.1016/j.heares.2007.02.009

Handle:

https://hdl.handle.net/2376/118223

PMCID: PMC1950695

PMID: 17412539

Files and links (1)

url

https://doi.org/10.1016/j.heares.2007.02.009View

Published (Version of record) Open

Abstract

Cochlear Nerve - physiopathology

Presbycusis - physiopathology

Inferior Colliculi - physiopathology

Neural Inhibition

Acoustic Stimulation

Mice, Inbred C57BL

Presbycusis - pathology

Auditory Threshold

Animals

Evoked Potentials, Auditory, Brain Stem

Fourier Analysis

Inferior Colliculi - pathology

Neuronal Plasticity

Cochlear Nerve - pathology

Aging

Mice, Inbred CBA

Mice

Auditory Perception

Disease Models, Animal

Individuals with age-related hearing loss often have difficulty understanding complex sounds such as basic speech. The C57BL/6 mouse suffers from progressive sensorineural hearing loss and thus is an effective tool for dissecting the neural mechanisms underlying changes in complex sound processing observed in humans. Neural mechanisms important for processing complex sounds include multiple tuning and combination sensitivity, and these responses are common in the inferior colliculus (IC) of normal hearing mice. We examined neural responses in the IC of C57Bl/6 mice to single and combinations of tones to examine the extent of spectral integration in the IC after age-related high frequency hearing loss. Ten percent of the neurons were tuned to multiple frequency bands and an additional 10% displayed non-linear facilitation to the combination of two different tones (combination sensitivity). No combination-sensitive inhibition was observed. By comparing these findings to spectral integration properties in the IC of normal hearing CBA/CaJ mice, we suggest that high frequency hearing loss affects some of the neural mechanisms in the IC that underlie the processing of complex sounds. The loss of spectral integration properties in the IC during aging likely impairs the central auditory system's ability to process complex sounds such as speech.

Metrics

5 Record Views

Details

Title: Excitatory, inhibitory and facilitatory frequency response areas in the inferior colliculus of hearing impaired mice
Creators: Richard A Felix, 2nd - School of Biological Sciences, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, United States
Christine V Portfors
Publication Details: Hearing research, Vol.228(1-2), pp.212-229
Academic Unit: Office of the Provost
Publisher: Netherlands
Grant note: R01 DC004733 / NIDCD NIH HHS R01 DC004733-05 / NIDCD NIH HHS R01 DC004733-04S1 / NIDCD NIH HHS R01 DC04733 / NIDCD NIH HHS
Identifiers: 99900548287901842
Language: English
Resource Type: Journal article