Journal article
Experimental challenge models for Johne's disease: A review and proposed international guidelines
Veterinary microbiology, Vol.122(3), pp.197-222
2007
Handle:
https://hdl.handle.net/2376/107109
PMID: 17467201
Abstract
An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a “best fit” JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host–pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of
Mycobacterium avium subsp.
paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
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Details
- Title
- Experimental challenge models for Johne's disease: A review and proposed international guidelines
- Creators
- Murray E Hines - Tifton Veterinary Diagnostic and Investigational Laboratory, University of Georgia, P.O. Box 1389, 43 Brighton Road, Tifton, GA 31793, USAJudith R Stabel - USDA-ARS, National Animal Disease Center, Ames, IA 50010, USARaymond W Sweeney - Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USAFrank Griffin - HOD Department of Microbiology and Immunology, University of Otago, Dunedin, New ZealandAdel M Talaat - Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USADouwe Bakker - Department of Bacteriology and TSEs, CIDC-Lelystad, Edelhertweg, Lelystad, The NetherlandsGeart Benedictus - Animal Health Service, Drachten, The NetherlandsWilliam C Davis - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USAGeoffrey W de Lisle - AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New ZealandIan A Gardner - Department of Medicine and Epidemiology, School of Veterinary Medicine, Univerisity of California, Davis, CA 95616, USARamon A Juste - Department of Animal Health, Basque Institute for Agricultural Research and Development (NEIKER), Berreaga, 1, 48160 Derio, Bizkaia, SpainVivek Kapur - Biomedical Genomics Center, University of Minnesota, St. Paul, MN 55108, USAAd Koets - Department of Farm Animal Health, Epidemiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The NetherlandsJim McNair - Agri-Food and Biosciences Institute, Bacteriology Department, Veterinary Sciences Division, Stormont, Belfast BT4 3SD, UKGreg Pruitt - Pfizer Animal Health, Veterinary Medicine Research and Development, Kalamazoo, MI 49001, USARobert H Whitlock - Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA
- Publication Details
- Veterinary microbiology, Vol.122(3), pp.197-222
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546874401842
- Language
- English
- Resource Type
- Journal article