Journal article
Experimental nebulization of American bison ( Bison bison) with low doses of ovine herpesvirus 2 from sheep nasal secretions
Veterinary microbiology, Vol.143(2), pp.389-393
2010
Handle:
https://hdl.handle.net/2376/106827
PMID: 20018461
Abstract
Malignant catarrhal fever (MCF), caused by ovine herpesvirus 2 (OvHV-2), is an important cause of mortality in ranched American bison and domestic cattle in North America. Previous studies showed that bison can be infected by intranasal nebulization with sheep nasal secretions containing OvHV-2 and provided preliminary information on viral doses required for infection and disease progression. The goals of this study were to establish optimal minimal infectious and minimal lethal doses of OvHV-2 by the intranasal route in bison, evaluate the influence of dose on incubation period and other clinical parameters and determine if bison seropositive for antibody against MCF-group viruses are resistant to developing MCF after intranasal challenge. In this study, the minimal infectious dose and minimal lethal dose overlap, suggesting that experimental production of subclinically infected bison is impractical. Dose is inversely related to both incubation period and the period between nebulization and first detection of >1000 OvHV-2 DNA copies/500
ng total DNA in peripheral blood leukocytes. Interestingly, all of the bison seropositive for anti-MCF-group viral antibody prior to inoculation died of MCF after nebulization. We conclude that previous exposure to an MCF-group virus does not necessarily provide resistance to OvHV-2-induced MCF in bison.
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Details
- Title
- Experimental nebulization of American bison ( Bison bison) with low doses of ovine herpesvirus 2 from sheep nasal secretions
- Creators
- Katherine L Gailbreath - Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, Pullman, WA 99164-6630, United StatesDonal O’Toole - Wyoming State Veterinary Laboratory, University of Wyoming, Laramie, WY 82070, United StatesNaomi S Taus - Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, Pullman, WA 99164-6630, United StatesDonald P Knowles - Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, Pullman, WA 99164-6630, United StatesJ. Lindsay Oaks - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, United StatesHong Li - Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, Pullman, WA 99164-6630, United States
- Publication Details
- Veterinary microbiology, Vol.143(2), pp.389-393
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546698001842
- Language
- English
- Resource Type
- Journal article