Journal article
Exploring Spatiotemporal Organization of SCN Circuits
Cold Spring Harbor Symposia on Quantitative Biology, Vol.72(1), pp.527-541
2007
Handle:
https://hdl.handle.net/2376/102662
PMCID: PMC3281753
PMID: 18419312
Abstract
Suprachiasmatic nucleus neuroanatomy has been a subject of intense interest since the discovery of the SCN’s function as a brain clock and subsequent studies revealing substantial heterogeneity of its component neurons. Understanding the network organization of the SCN has become increasingly relevant in the context of studies showing that its functional circuitry, evident in the spatial and temporal expression of clock genes, can be reorganized by inputs from the internal and external environment. Although multiple mechanisms have been proposed for coupling among SCN neurons, relatively little is known of the precise pattern of SCN circuitry. To explore SCN networks, we examine responses of the SCN to various photic conditions, using in vivo and in vitro studies with associated mathematical modeling to study spatiotemporal changes in SCN activity. We find an orderly and reproducible spatiotemporal pattern of oscillatory gene expression in the SCN, which requires the presence of the ventrolateral core region. Without the SCN core region, behavioral rhythmicity is abolished in vivo, whereas low-amplitude rhythmicity can be detected in SCN slices in vitro, but with loss of normal topographic organization. These studies reveal SCN circuit properties required to signal daily time.
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Details
- Title
- Exploring Spatiotemporal Organization of SCN Circuits
- Creators
- L Yan - Department of Psychology, Columbia University, New York, New York 10027I Karatsoreos - Department of Psychology, Columbia University, New York, New York 10027J LeSauter - Department of Barnard College, New York, New York 10027D.K Welsh - Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093S Kay - Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093D Foley - Department of Economics, Graduate Faculty, New School University, New York, New York 10003R Silver - Department of Psychology, Columbia University, New York, New York 10027
- Publication Details
- Cold Spring Harbor Symposia on Quantitative Biology, Vol.72(1), pp.527-541
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Grant note
- R01 NS037919-02S1 || NS / National Institute of Neurological Disorders and Stroke : NINDS R01 MH075045-02 || MH / National Institute of Mental Health : NIMH K08 MH067657-01 || MH / National Institute of Mental Health : NIMH
- Identifiers
- 99900546630401842
- Language
- English
- Resource Type
- Journal article