Journal article
Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO)
International journal of cancer, Vol.135(8), pp.1918-1930
10/15/2014
Handle:
https://hdl.handle.net/2376/116356
PMCID: PMC4126868
PMID: 24615328
Abstract
While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 controls who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17–1.45) for all histological types combined, 1.26 (95% CI: 1.10–1.44) for adenocarcinoma, 1.41 (95% CI: 0.99–1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89–2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62–5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for non-small cell lung cancers (OR=2.11, 95% CI: 1.11–4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.
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Details
- Title
- Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO)
- Creators
- Claire H Kim - Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), 71-225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA 90095, USAYuan-Chin Amy Lee - Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), 71-225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA 90095, USARayjean J Hung - Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario M5T 3L9, CanadaSheila R McNallan - Mayo Clinic Cancer Center, Rochester, MN, USAMichele L Cote - Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USAWei-Yen Lim - Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, SingaporeShen-Chih Chang - Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), 71-225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA 90095, USAJin Hee Kim - Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, KoreaDonatella Ugolini - Internal Medicine, University of Genoa, Genoa, ItalyYing Chen - Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UKTriantafillos Liloglou - Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UKAngeline S Andrew - Section of Biostatistics & Epidemiology, Dartmouth Medical School, Lebanon, NH, USATracy Onega - Section of Biostatistics & Epidemiology, Dartmouth Medical School, Lebanon, NH, USAEric J Duell - Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, SpainJohn K Field - Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UKPhilip Lazarus - Washington State University College of Pharmacy, Spokane, WA, USALoic Le Marchand - University of Hawaii, Honolulu, HI, USAMonica Neri - Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, ItalyPaolo Vineis - MRC/HPA Centre for Environment and Health, School of Public Health, Imperial College, London, UKChikako Kiyohara - Department of Preventive Medicine, Kyushu University, Fukuoka, JapanYun-Chul Hong - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaHal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USAKeitaro Matsuo - Department of Preventive Medicine, Kyushu University, Fukuoka, JapanKazuo Tajima - Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Tsu, Mie, JapanDavid C Christiani - Department of Environmental Health, Harvard University, Boston, MA, USAJohn R McLaughlin - Cancer Care Ontario, Toronto, Ontario, CanadaVladimir Bencko - Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech RepublicIvana Holcatova - Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech RepublicPaolo Boffetta - The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, USAPaul Brennan - International Agency for Research on Cancer, Lyon, FranceEleonora Fabianova - Department of Occupational Health and Toxicology, Regional Authority of Public Health, Banska Bystrica, SlovakiaLenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czech RepublicVladimir Janout - Department of Preventive Medicine, Palacky University, Olomouc, Czech RepublicJolanta Lissowska - Department of Cancer Epidemiology and Prevention, Cancer Center and Maria Sklodowska-Curie Institute of Oncology, Warsaw, PolandDana Mates - Occupational Health Department, Institute of Public Health, Bucharest, RomaniaPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryNeonila Szeszenia-Dabrowska - Department of Occupational and Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lódz, PolandAnush Mukeria - Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre, Moscow, RussiaDavid Zaridze - Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Centre, Moscow, RussiaAdeline Seow - Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, SingaporeAnn G Schwartz - Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USAPing Yang - Mayo Clinic Cancer Center, Rochester, MN, USAZuo-Feng Zhang - Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), 71-225 CHS, 650 Charles E Young Drive, South, Los Angeles, CA 90095, USA
- Publication Details
- International journal of cancer, Vol.135(8), pp.1918-1930
- Academic Unit
- Pharmaceutical Sciences, Department of
- Identifiers
- 99900548025301842
- Language
- English
- Resource Type
- Journal article