Journal article
Extracellular ATP acts as a damage-associated molecular pattern (DAMP) signal in plants
Frontiers in plant science, Vol.5, pp.446-446
09/03/2014
Handle:
https://hdl.handle.net/2376/106797
PMID: 25232361
Abstract
As sessile organisms, plants have evolved effective mechanisms to protect themselves from environmental stresses. Damaged (i.e., wounded) plants recognize a variety of endogenous molecules as danger signals, referred to as damage-associated molecular patterns (DAMPs). ATP is among the molecules that are released by cell damage, and recent evidence suggests that ATP can serve as a DAMP. Although little studied in plants, extracellular ATP is well known for its signaling roles in animals, including acting as a DAMP during the inflammatory response and wound healing. If ATP acts outside the cell, then it is reasonable to expect that it is recognized by a plasma membrane-localized receptor. Recently, DORN1, a lectin receptor kinase, was shown to recognize extracellular ATP in
Arabidopsis
. DORN1 is the founding member of a new purinoceptor subfamily, P2K (P2 receptor kinase), which is plant-specific. P2K1 (DORN1) is required for ATP-induced cellular responses (e.g., cytosolic Ca
2+
elevation, MAPK phosphorylation, and gene expression). Genetic analysis of loss-of-function mutants and overexpression lines showed that P2K1 participates in the plant wound response, consistent with the role of ATP as a DAMP. In this review, we summarize past research on the roles and mechanisms of extracellular ATP signaling in plants, and discuss the direction of future research on extracellular ATP as a DAMP signal.
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Details
- Title
- Extracellular ATP acts as a damage-associated molecular pattern (DAMP) signal in plants
- Creators
- Kiwamu Tanaka - Department of Plant Pathology, Washington State UniversityJeongmin Choi - Division of Plant Sciences and Biochemistry, Christopher S. Bond Life Sciences Center, University of MissouriYangrong Cao - Division of Plant Sciences and Biochemistry, Christopher S. Bond Life Sciences Center, University of MissouriGary Stacey - Division of Plant Sciences and Biochemistry, Christopher S. Bond Life Sciences Center, University of Missouri
- Publication Details
- Frontiers in plant science, Vol.5, pp.446-446
- Academic Unit
- Plant Pathology, Department of
- Publisher
- Frontiers Media S.A
- Identifiers
- 99900546733901842
- Language
- English
- Resource Type
- Journal article