Journal article
Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system
Peptides (New York, N.Y. : 1980), Vol.23(1), pp.221-246
2002
Handle:
https://hdl.handle.net/2376/105673
PMID: 11814638
Abstract
Considerable evidence now suggests an interrelationship among long-term potentiation (LTP), extracellular matrix (ECM) reconfiguration, synaptogenesis, and memory consolidation within the mammalian central nervous system. Extracellular matrix molecules provide the scaffolding necessary to permit synaptic remodeling and contribute to the regulation of ionic and nutritional homeostasis of surrounding cells. These molecules also facilitate cellular proliferation, movement, differentiation, and apoptosis. The present review initially focuses on characterizing the ECM and the roles of cell adhesion molecules (CAMs), matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), in the maintenance and degradation of the ECM. The induction and maintenance of LTP is described. Debate continues over whether LTP results in some form of synaptic strengthening and in turn promotes memory consolidation. Next, the contribution of CAMs and TIMPs to the facilitation of LTP and memory consolidation is discussed. Finally, possible roles for angiotensins, MMPs, and tissue plasminogen activators in the facilitation of LTP and memory consolidation are described. These enzymatic pathways appear to be very important to an understanding of dysfunctional memory diseases such as Alzheimer’s disease, multiple sclerosis, brain tumors, and infections.
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Details
- Title
- Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system
- Creators
- John W Wright - Department of Psychology, Washington State University, PO Box 644820, Pullman, WA 99164-4820, USAEnikö A Kramár - Program in Neuroscience, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USAStarla E Meighan - Program in Neuroscience, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USAJoseph W Harding - Department of Psychology, Washington State University, PO Box 644820, Pullman, WA 99164-4820, USA
- Publication Details
- Peptides (New York, N.Y. : 1980), Vol.23(1), pp.221-246
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546925501842
- Language
- English
- Resource Type
- Journal article