Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees

Paul E Stamets; Nicholas L Naeger; Jay D Evans; Jennifer O Han; Brandon K Hopkins; Dawn Lopez; Henry M Moershel; Regan Nally; David Sumerlin; Alex W Taylor; Lori M Carris; Walter S Sheppard

doi:10.1038/s41598-018-32194-8

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Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees

Journal article

Open access

Peer reviewed

Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees

Paul E Stamets, Nicholas L Naeger, Jay D Evans, Jennifer O Han, Brandon K Hopkins, Dawn Lopez, Henry M Moershel, Regan Nally, David Sumerlin, Alex W Taylor, …

Scientific reports, Vol.8(1), pp.13936-6

10/04/2018

DOI: https://doi.org/10.1038/s41598-018-32194-8

Handle:

https://hdl.handle.net/2376/106981

PMCID: PMC6172205

PMID: 30287824

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https://doi.org/10.1038/s41598-018-32194-8View

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Abstract

Bees - parasitology

RNA Viruses - isolation & purification

Coriolaceae - growth & development

Insect Viruses - isolation & purification

Administration, Oral

Plant Extracts - pharmacology

Bees - virology

Ganoderma - growth & development

Dose-Response Relationship, Drug

Plant Extracts - administration & dosage

Animals

Colony Collapse - prevention & control

Coriolaceae - chemistry

Varroidae - virology

Bees - drug effects

Female

Mycelium - chemistry

Ganoderma - chemistry

Plant Extracts - therapeutic use

Waves of highly infectious viruses sweeping through global honey bee populations have contributed to recent declines in honey bee health. Bees have been observed foraging on mushroom mycelium, suggesting that they may be deriving medicinal or nutritional value from fungi. Fungi are known to produce a wide array of chemicals with antimicrobial activity, including compounds active against bacteria, other fungi, or viruses. We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) and reishi (Ganoderma) fungi reduced the levels of honey bee deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-dependent manner. In field trials, colonies fed Ganoderma resinaceum extract exhibited a 79-fold reduction in DWV and a 45,000-fold reduction in LSV compared to control colonies. These findings indicate honey bees may gain health benefits from fungi and their antimicrobial compounds.

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Title: Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees
Creators: Paul E Stamets - Fungi Perfecti, LLC. Olympia, Washington, USA
Nicholas L Naeger - Washington State University. Pullman, Washington, USA
Jay D Evans - USDA-ARS Beltsville, Maryland, USA
Jennifer O Han - Washington State University. Pullman, Washington, USA
Brandon K Hopkins - Washington State University. Pullman, Washington, USA
Dawn Lopez - USDA-ARS Beltsville, Maryland, USA
Henry M Moershel - Fungi Perfecti, LLC. Olympia, Washington, USA
Regan Nally - Fungi Perfecti, LLC. Olympia, Washington, USA
David Sumerlin - Fungi Perfecti, LLC. Olympia, Washington, USA
Alex W Taylor - Fungi Perfecti, LLC. Olympia, Washington, USA
Lori M Carris - Washington State University. Pullman, Washington, USA
Walter S Sheppard - Washington State University. Pullman, Washington, USA. shepp@wsu.edu
Publication Details: Scientific reports, Vol.8(1), pp.13936-6
Academic Unit: Entomology, Department of; Plant Pathology, Department of
Publisher: England
Identifiers: 99900546736801842
Language: English
Resource Type: Journal article