Journal article
Eyeball-Like Yolk Shell Bimetallic Nanoparticles for Synergistic Photodynamic-Photothermal Therapy
ACS applied bio materials, Vol.3(9), pp.5922-5929
09/21/2020
PMID: 35021820
Abstract
Noble metal-based nanomaterials offer great potential as cargoes for multifunctional cancer treatment. In this research, Au eyeball-like nanoparticles (NPs) with open-mouthed Pd shells were synthesized and their surface was functionalized with cell-targeting ligand folic acid (FA) and photodynamic agent Chlorin e6 (Ce6). Due to the broad near-infrared (NIR) absorption band of eyeball-like bimetallic Au and Pd, the photothermal therapy effects of this nanomaterial were studied in MCF-7 cancer cells. The anchored Ce6 not only addressed the hypoxia issue of tumor cells but also exhibited remarkable photodynamic efficacy upon irradiation. Results showed that the obtained Au@Pd-PEG-FA-Ce6 (APPFC) NPs were selectively accumulated at the tumor site and induced cell apoptosis effectively due to the target specificity and synergistic phototherapy effect. The high specificity, desirable biosafety, fast delivery, and drug functionalization demonstrated eyeball-like Au@Pd NPs are promising candidate for multifunctional therapy of breast cancer.
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Details
- Title
- Eyeball-Like Yolk Shell Bimetallic Nanoparticles for Synergistic Photodynamic-Photothermal Therapy
- Creators
- Xiaoli Cai - Washington State UniversityShichao Ding - Washington State UniversityQiurong Shi - Washington State UniversityZhaoyuan Lyu - Washington State UniversityDong Liu - Washington State UniversityWen-ji Dong - Washington State Univ, Gene & Linda Voiland Sch Chem Engn & Bioengn, Pullman, WA 99164 USAMin Du - Washington State Univ, Dept Anim Sci, Lab Nutrigen & Growth Biol, Pullman, WA 99164 USAPrashanta Dutta - Washington State UniversityYang Song - Washington State UniversityDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- ACS applied bio materials, Vol.3(9), pp.5922-5929
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 8
- Grant note
- WSU start-up fund
- Identifiers
- 99901227640101842
- Language
- English
- Resource Type
- Journal article