Journal article
FAMILY HISTORY OF CANCER: POOLED ANALYSIS IN THE INTERNATIONAL HEAD AND NECK CANCER EPIDEMIOLOGY (INHANCE) CONSORTIUM
International journal of cancer, Vol.124(2), pp.394-401
01/15/2009
Handle:
https://hdl.handle.net/2376/106237
PMCID: PMC3711193
PMID: 18814262
Abstract
Alcohol and tobacco consumption are well recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual- level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models, and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC (OR=1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8), and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR=1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR=1.3, 95% CI 1.1-1.5). No association was observed for family history of non-tobacco related neoplasms and the risk of HNC (OR=1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.
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- Title
- FAMILY HISTORY OF CANCER: POOLED ANALYSIS IN THE INTERNATIONAL HEAD AND NECK CANCER EPIDEMIOLOGY (INHANCE) CONSORTIUM
- Creators
- Eva Negri - Istituto di Ricerche Farmacologiche “Mario Negri”, Milan ItalyPaolo Boffetta - International Agency for Research on Cancer, Lyon, FranceJulien Berthiller - International Agency for Research on Cancer, Lyon, FranceXavier Castellsague - Institut Catalá d’Oncologia, Barcelona, SpainMaria Paula Curado - International Agency for Research on Cancer, Lyon, FranceLuigino Dal Maso - Aviano Cancer Centre, Aviano, ItalyAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilEleonora Fabianova - Specialized State Health Institute, Banská Bystrica, SlovakiaLeticia Fernandez - Institute of Oncology and Radiobiology, Havan, CubaVictor Wünsch-Filho - Institute of Oncology and Radiobiology, Havan, CubaSilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceRichard B Hayes - National Cancer Institute, Bethesda, MD, USARolando Herrero - Instituto de Investigación Epidemiológica, San José, Costa RicaSergio Koifman - Escola Nacional de Saude Publica, Rio de Janeiro, BrazilPhilip Lazarus - Penn State College of Medicine, Hershey, PA, USAJuan J Lence - Institute of Oncology and Radiobiology, Havan, CubaFabio Levi - Institut de médecine sociale et préventive, Université de Lausanne, Lausanne, SwitzerlandDana Mates - Institut of Public Health, Bucharest, RomaniaElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAJose Eluf-Neto - Universidade de Sao Paulo, Sao Paulo, BrazilAndrew F Olshan - UNC School of Public Health, Chapel Hill, NC, USAPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryOxana Shangina - Cancer Research Centre, Moscow, RussiaErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, Texas, USANeonilia Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandRenato Talamini - Aviano Cancer Centre, Aviano, ItalyQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, Texas, USADeborah M Winn - National Cancer Institute, Bethesda, MD, USADavid Zaridze - Cancer Research Centre, Moscow, RussiaJolanta Lissowska - Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, PolandZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAGilles Ferro - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FranceCarlo La Vecchia - Istituto di Ricerche Farmacologiche “Mario Negri”, Milan ItalyMia Hashibe - International Agency for Research on Cancer, Lyon, France
- Publication Details
- International journal of cancer, Vol.124(2), pp.394-401
- Academic Unit
- Pharmaceutical Sciences, Department of
- Identifiers
- 99900546684401842
- Language
- English
- Resource Type
- Journal article