FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A

Mary Hunzicker-Dunn; Evelyn T Maizels

doi:10.1016/j.cellsig.2006.02.011

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FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A

Journal article

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Peer reviewed

FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A

Mary Hunzicker-Dunn and Evelyn T Maizels

Cellular signalling, Vol.18(9), pp.1351-1359

2006

DOI: https://doi.org/10.1016/j.cellsig.2006.02.011

Handle:

https://hdl.handle.net/2376/114931

PMCID: PMC1564187

PMID: 16616457

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Abstract

Protein kinase A

Mitogen-activated protein kinase

Follicle-stimulating hormone

Female reproduction

Hypoxia-induced factor 1

Histone H3

Follicle-stimulating hormone (FSH) is necessary and sufficient to induce maturation of ovarian follicles to a mature, preovulatory phenotype in the intact animal, resulting in the generation of mature eggs and production of estrogen. FSH accomplishes these actions by inducing a complex pattern of gene expression in target granulosa cells that is regulated by input from many different signaling cascades, including those for the extracellular regulated kinases (ERKs), p38 mitogen-activated protein kinases (MAPKs), and phosphatidylinositol-3 kinase (PI3K). The upstream kinase that appears to be responsible for initiating all of the signaling that regulates gene expression in these epithelial cells is protein kinase A (PKA). PKA not only signals to directly phosphorylate transcription factors like cAMP response element binding protein and to promote chromatin remodeling by phosphorylating histone H3, this versatile kinase also enhances the activity of the p38 MAPK, ERK, and PI3K pathways. Additionally, accumulating evidence suggests that activation of a single signaling cascade downstream of PKA is not sufficient to activate target gene expression. Rather, cross-talk between and among signaling cascades is required. We will review the signaling cascades activated by FSH in granulosa cells and how these cascades contribute to the regulation of select target gene expression.

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Title: FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A
Creators: Mary Hunzicker-Dunn
Evelyn T Maizels
Publication Details: Cellular signalling, Vol.18(9), pp.1351-1359
Academic Unit: Molecular Biosciences, School of
Publisher: Elsevier Inc
Identifiers: 99900547321301842
Language: English
Resource Type: Journal article