Facile Amide Formation via S-Nitrosothioacids

Jia Pan; Nelmi O Devarie-Baez; Ming Xian

doi:10.1021/ol1031393

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Facile Amide Formation via S-Nitrosothioacids

Journal article

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Facile Amide Formation via S-Nitrosothioacids

Jia Pan, Nelmi O Devarie-Baez and Ming Xian

Organic letters, Vol.13(5), pp.1092-1094

03/04/2011

DOI: https://doi.org/10.1021/ol1031393

Handle:

https://hdl.handle.net/2376/110307

PMCID: PMC3045635

PMID: 21271725

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https://doi.org/10.1021/ol1031393View

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Abstract

Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.

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Title: Facile Amide Formation via S-Nitrosothioacids
Creators: Jia Pan
Nelmi O Devarie-Baez
Ming Xian
Publication Details: Organic letters, Vol.13(5), pp.1092-1094
Academic Unit: Chemistry, Department of
Publisher: American Chemical Society
Identifiers: 99900547119301842
Language: English
Resource Type: Journal article