Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

Nelmi O Devarie-Baez; Ming Xian

doi:10.1021/ol9028447

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Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

Journal article

Peer reviewed

Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

Nelmi O Devarie-Baez and Ming Xian

Organic letters, Vol.12(4), pp.752-754

02/19/2010

DOI: https://doi.org/10.1021/ol9028447

Handle:

https://hdl.handle.net/2376/106486

PMID: 20078088

Abstract

Benzene Derivatives - chemical synthesis

Combinatorial Chemistry Techniques

Cyclization

Thiazoles - chemical synthesis

Sulfhydryl Compounds - chemistry

Thiazoles - chemistry

Molecular Structure

Catalysis

Benzene Derivatives - chemistry

A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reaction leading to the construction of the title compounds.

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Title: Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones
Creators: Nelmi O Devarie-Baez - Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
Ming Xian
Publication Details: Organic letters, Vol.12(4), pp.752-754
Academic Unit: Chemistry, Department of
Publisher: United States
Identifiers: 99900547067801842
Language: English
Resource Type: Journal article

Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

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