Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice

S T Kanaly; S A Hines; G H Palmer

doi:10.1128/IAI.61.11.4929-4932.1993

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Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice

Journal article

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Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice

S T Kanaly, S A Hines and G H Palmer

Infection and immunity, Vol.61(11), pp.4929-4932

11/1993

DOI: https://doi.org/10.1128/IAI.61.11.4929-4932.1993

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https://hdl.handle.net/2376/113071

PMCID: PMC281259

PMID: 8104903

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https://doi.org/10.1128/IAI.61.11.4929-4932.1993View

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Abstract

Pulmonary clearance of Rhodococcus equi requires functional T lymphocytes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleared virulent R. equi from the lungs while infection in CD4+ T-lymphocyte-deficient transgenic mice persisted. Although both CD4+ and CD8+ T cells function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.

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Title: Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice
Creators: S T Kanaly - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
S A Hines - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
G H Palmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
Publication Details: Infection and immunity, Vol.61(11), pp.4929-4932
Academic Unit: Veterinary Medicine, College of; Paul G. Allen School for Global Animal Health
Identifiers: 99900548124001842
Language: English
Resource Type: Journal article